GLYCINE ETHYL ESTER HYDROCHLORIDE CAS No. 623-33-6

Product Description

Glycine Ethyl Ester Hydrochloride, also known as Ethyl 2-aminoacetate hydrochloride, is a versatile organic compound. It is a white crystalline powder that is soluble in water and alcohol, with a slight ester-like odor and an acidic pH in solution. This compound has a melting point of 142–145 °C and is classified as an irritant to eyes, skin, and the respiratory tract, necessitating the use of gloves, eye protection, and proper ventilation during handling. It is stable under normal conditions but hydrolyzes in moist air. Glycine Ethyl Ester Hydrochloride is widely used in organic synthesis as a building block for more complex molecules, in pharmaceutical research as an intermediate for peptide synthesis and prodrug development, and in biochemical studies to investigate amino acid absorption and ester metabolism. It is also related to compounds such as Glycine Methyl Ester Hydrochloride and N-protected glycine esters, which share similar structures and applications.

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Product Use & Characteristics

Properties

• Chemical Formula: C₄H₁₀ClNO₂

• Molecular Weight: 139.58 g/mol

• Appearance: White crystalline powder

• Solubility: Soluble in water and alcohol; insoluble in non-polar solvents like ether and petroleum ether

• Melting Point: 142–145 °C (decomposes)

• pH: Acidic (in solution)

• Odor: Slight ester-like odor

Characteristics

• Reactivity: The amino and ester groups in the molecule are highly reactive, allowing it to participate in various chemical reactions such as acylation, transesterification, and ester hydrolysis.

• Stability: Stable under normal conditions but hydrolyzes in moist air.

• Hygroscopicity: Absorbs moisture from the air, so it must be stored in a cool, dry, and well-ventilated place.

Uses

• Organic Synthesis:

  • Used as a building block for more complex organic molecules.

  • Serves as a precursor for the synthesis of peptides, amino acid derivatives, and other organic compounds.

• Pharmaceutical Research:

  • Intermediate in the synthesis of peptides, prodrugs, and glycine-based compounds.

  • Used in the development of antibacterial, antiviral, and other biologically active drugs.

• Biochemical Research:

  • Investigated in studies of amino acid transport, metabolism, and ester hydrolysis.

  • Used to study amino acid absorption and ester metabolism in biological systems.

Safety and Handling

• Hazards: Irritant to eyes, skin, and respiratory tract.

• Precautions: Use gloves, eye protection, and work in well-ventilated areas.

• Storage: Store in a cool, dry, well-ventilated place; keep the container tightly closed.

Related Compounds

• Glycine Methyl Ester Hydrochloride: Similar structure and applications.

• Glycine: The parent amino acid.

• N-Protected Glycine Esters: Used for selective peptide coupling.

Synthesis Methods

• Esterification Reaction: Glycine reacts with ethanol in the presence of an acidic catalyst (e.g., concentrated sulfuric acid). Ethanol is removed by distillation, and hydrochloric acid is added for acidification. The final product is obtained through crystallization, filtration, and drying.

• Alternative Method: The free base of glycine ethyl ester can be reacted with hydrochloric acid, though this method is less common.

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Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.