PHENYLEPHRINE HYDROCHLORIDE CAS No. 61-76-7

Product Description

Phenylephrine Hydrochloride is a synthetic sympathomimetic amine that primarily acts as an α₁-adrenergic receptor agonist. It is widely used for its vasoconstrictive properties to relieve nasal congestion, elevate blood pressure, and dilate pupils. With a molecular formula of C₉H₁₃NO₂·HCl and a molecular weight of 203.67 g/mol, it is a derivative of phenylethanolamine. By selectively stimulating α₁ receptors, Phenylephrine Hydrochloride causes vasoconstriction, leading to reduced nasal mucosal swelling, increased blood pressure, and pupil dilation.

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Product Use & Characteristics

Physical and Chemical Properties

• Appearance: White to off-white crystalline powder.

• Solubility: Freely soluble in water and ethanol.

• Stability: Hygroscopic; stable under normal conditions but should be protected from light.

Uses

1. Relief of Nasal Congestion: Commonly used in nasal sprays and oral tablets (e.g., Sudafed PE) to alleviate nasal congestion caused by colds, allergies, or sinusitis.

2. Blood Pressure Elevation: Administered intravenously to treat hypotension, especially during anesthesia or in patients with shock.

3. Ophthalmic Use: Employed as a mydriatic agent for pupil dilation before eye exams or surgeries, although its effect is relatively weak and short-lived.

Pharmacological Actions

• Vasoconstriction: Acts on α₁ receptors in blood vessels, causing smooth muscle contraction, increased peripheral resistance, and elevated blood pressure. It also reduces nasal mucosal swelling by constricting nasal blood vessels.

• Cardiac Effects: Has minimal impact on β₁ receptors (heart), resulting in less effect on heart rate and myocardial contractility compared to adrenaline or ephedrine.

• Mydriasis: Excites the α₁ receptors in the iris radiata muscle, causing mild and short-lived pupil dilation.

Adverse Reactions and Precautions

• Common Side Effects: Headache, nervousness, increased blood pressure, insomnia.

• Serious Side Effects: Reflex bradycardia, hypertension, arrhythmias.

• Contraindications: Severe hypertension, ventricular tachycardia, narrow-angle glaucoma (ophthalmic use).

• Precautions: Monitor blood pressure and heart rate during use, especially with intravenous administration. Avoid prolonged use of nasal sprays to prevent rebound congestion.

Dosage Forms and Administration

• Oral Tablets: 10 mg, taken every 4 hours, up to 4 times daily.

• Nasal Spray: 0.25%–1%, 1-2 sprays per nostril every 4-6 hours.

• IV Solution: 10 mg/mL, diluted before use.

• Ophthalmic Drops: 2.5%, 10%, 1-2 drops per eye for mydriasis.

Why us!

Sigma Chemical Group is a major chemical enterprise headquartered in Hangzhou, Zhejiang Province, with a diversified portfolio of subsidiaries including Qingdao Sigma Chemical Co., Ltd., Henan Sigma Biotechnology Co., Ltd., Nanchang Sigma Chemical Co., Ltd., and Jinan Sigma Chemical Co., Ltd. Established on January 16, 2017, Qingdao Sigma Chemical Co., Ltd. operates as a micro-sized chemical product wholesaler with a registered capital of RMB 100,000. Led by legal representative Yang Yuwen and based at 2-1-2301, Jiahe Xinxing, No. 130 Shandong Road, Shibei District, Qingdao, the company’s operations span chemicals, machinery equipment, and import-export services. Henan Sigma Biotechnology Co., Ltd., located in Dongmafang, Muye District, Xinxiang City, Henan Province, specializes in the sales of pesticides, pharmaceuticals, veterinary drugs, and mixed feed additive series, including products like adenine, florfenicol injection, carbasalate calcium soluble powder, and cefotaxime sodium chloride injection. Guided by a win-win and innovative business philosophy, the company employs a modern management approach and customer-centric service, upholding integrity, diligence, and a commitment to quality, thereby earning customer trust through diverse product offerings and competitive pricing. Nanchang Sigma Chemical Co., Ltd., situated in Nanchang, Jiangxi Province, is dedicated to producing high-purity plant extracts, emphasizing eco-friendly, non-toxic chemical raw materials that generate no environmental pollutants. Jinan Sigma Chemical Co., Ltd., located in Jinan, the capital of Shandong Province known as the "City of Springs," focuses on manufacturing active pharmaceutical ingredients (APIs) and pharmaceutical intermediates. The company maintains long-term industry-academia-research collaborations with Shandong University and Qilu University of Technology, continuously enhancing R&D investments to drive innovation and growth.