Rimantadine hydrochloride CAS No. 1501-84-4

Product Description

Rimantadine Hydrochloride is a synthetic antiviral drug primarily used to prevent and treat influenza A infections. It is a derivative of adamantane, structurally related to amantadine, and exists as a hydrochloride salt form. This medication works by inhibiting the M2 ion channel protein of influenza A viruses, thereby blocking the uncoating process of the virus after it enters host cells. Without uncoating, viral replication is halted. Rimantadine hydrochloride is classified as a chemical used to treat viral infections, prevent influenza, and protect the respiratory system indirectly through its antiviral action.

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Product Use & Characteristics

Properties and Uses

• Chemical Name: α-Methyl-1-adamantane methylamine hydrochloride

• Molecular Formula: C₁₂H₂₁N·HCl

• Molecular Weight: 215.76 g/mol

• Appearance: White crystalline powder

• Solubility: Freely soluble in water

• Stability: Stable under acidic conditions; should be stored away from light.

Mechanism of Action

Rimantadine specifically targets the M2 ion channel protein of influenza A viruses, preventing the release of viral RNA into the host cell and inhibiting viral replication. It is only effective against influenza A and has no effect on influenza B or other respiratory viruses.

Uses

• Prevention of Influenza A: Suitable for high-risk populations (e.g., elderly, those with chronic diseases) during flu season or after exposure to infected individuals. Adults typically take 100 mg once or twice daily for 10-14 days.

• Treatment of Influenza A: For adults diagnosed with influenza A within 48 hours of symptom onset. The usual dosage is 100 mg twice daily for 5-7 days.

• Other Applications: Sometimes studied for potential use in Parkinson’s disease or against other RNA viruses, though not widely approved for these purposes.

Dosage (Adults)

• Prophylaxis: 100 mg once or twice daily

• Treatment: 100 mg twice daily (adjusted for age and renal function)

Side Effects

Common side effects include nausea, dizziness, insomnia, and nervousness. Rare central nervous system effects may occur, especially in the elderly.

Precautions

Use with caution in patients with seizure disorders, renal impairment, or liver dysfunction. It is not effective against influenza B.

Comparison to Amantadine

• Potency: Rimantadine is more potent than amantadine.

• CNS Side Effects: Rimantadine has fewer central nervous system side effects compared to amantadine.

• Metabolism: Rimantadine is metabolized in the liver, while amantadine is primarily excreted renally.

• Spectrum: Both are effective only against influenza A.

Why us!

Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.