2-deoxy-D-Ribose CAS No. 533-67-5

Product Description

2-Deoxy-D-ribose is a naturally occurring deoxy sugar derived from D-ribose, distinguished by the absence of an oxygen atom at the 2-carbon position. It is an aldopentose and a critical structural component of DNA, forming part of its sugar-phosphate backbone. It participates in several biological functions, including cellular metabolism and energy production, and is commonly found as a white crystalline powder soluble in water, ethanol, and DMSO.

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Product Use & Characteristics

• Chemical Identity: A deoxy sugar (missing an oxygen atom at carbon-2), aldopentose, and component of DNA.

• Biological Functions:

  • Fundamental to DNA structure.

  • Involved in energy metabolism (notably ATP-related pathways).

  • Found in multiple organisms as a metabolic intermediate.

• Physical Properties:

  • White/off-white crystalline powder.

  • Soluble in water, ethanol, and DMSO.

  • Melting point: ~89–90°C.

  • Exhibits optical activity.

• Applications:

  • Used in supplements for energy and recovery.

  • Researched for heart health (e.g., improving myocardial metabolism).

  • Tool in cellular metabolism studies (e.g., chronic fatigue syndrome).

• Biomedical Research:

  • Promotes angiogenesis (formation of blood vessels), aiding in wound healing.

  • Combined with lidocaine in hydrogel to relieve pain and enhance healing in wound models.

• Toxicology and Cellular Effects:

  • Induces ferroptosis (a type of cell death) in renal tubular epithelial cells via degradation of the xCT protein by the ubiquitin-proteasome system.

  • Reduces intracellular cystine and glutathione, promoting oxidative damage.

• Polymer Chemistry:

  • Source for bio-based aliphatic polycarbonates via ring-opening polymerization.

  • Used in developing biodegradable, biocompatible polymers from sugars and CO₂.

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Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.