RH-34
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Product Description
RH-34 (CAS 1028307-48-3) is a white, crystalline research chemical with the molecular formula C₁₈H₁₉N₃O₃ and a base molecular weight of 325 g mol⁻¹. Originally derived from the 5-HT₂A antagonist ketanserin, it behaves as a potent and selective partial agonist at the 5-HT₂A serotonin receptor rather than at cannabinoid sites, making it valuable for neuropharmacological studies. Prepared and analytically characterized as its hydrochloride salt (mp 166 °C; MW 361 g mol⁻¹) by the DEA Special Testing and Research Laboratory, RH-34 shows characteristic UV maxima at 226, 279 and 312 nm and distinctive GC-MS, ¹H-NMR and FT-IR signatures. Despite its scientific utility, the compound has no approved medical use, is illegal for human consumption, and is classified as a dangerous substance because its high receptor potency can precipitate unpredictable and severe toxic effects, posing a significant public-health risk.
Uses and Applications
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Primary Application: Based on its classification and the context of the DEA's involvement, RH-34 is a research chemical. Its primary application is for scientific research and forensic analysis.
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Pharmacological Activity: The supplementary text identifies it as a potent synthetic cannabinoid receptor agonist, specifically targeting the CB1 receptor. This suggests its research applications are related to studying the endocannabinoid system.
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Regulatory Status: It has no approved medical use and is an illicit controlled substance in many countries. It is considered a drug of abuse and is often falsely marketed as "herbal incense" or "legal weed."
Chemical and Physical Properties
Chemical Identity:
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IUPAC Name: 3-[2-[(2-methoxyphenyl)methylamino]ethyl]-1H-quinazoline-2,4-dione
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Molecular Formula: C₁₈H₁₉N₃O₃
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CAS Number: 1028307-48-3
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Other Identifiers: UNII (A31AED225O), DSSTox (DTXSID80434687), Wikidata (Q7276696)
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Canonical SMILES: COC1=CC=CC=C1CNCCN2C(=O)C3=CC=CC=C3NC2=O
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InChIKey: NUAJBITWGGTZCM-UHFFFAOYSA-N
Physical and Chemical Properties:
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Molecular Weight:
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Base Form: 325.4 g/mol (PubChem), 325 g/mol (DEA Monograph)
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HCl Salt: 361 g/mol (DEA Monograph)
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Melting Point: 166.1 °C (for the HCl salt form, per DEA Monograph).
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XLogP3: 1.7 (indicates moderate lipophilicity).
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Hydrogen Bond Donor Count: 2
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Hydrogen Bond Acceptor Count: 4
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Rotatable Bond Count: 6
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Topological Polar Surface Area (TPSA): 70.7 Ų
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UV-Vis Absorption Maxima (λmax): 226.1 nm, 278.8 nm, 311.5 nm (per DEA Monograph).
Spectral Data:
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¹H NMR: Data acquired in CD₃OD at 400 MHz (spectrum provided in DEA Monograph).
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Mass Spectrometry: GC-MS data is available, with a retention time of 18.057 minutes under specified conditions (DEA Monograph).
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IR Spectroscopy: FTIR-ATR spectrum shows characteristic peaks, including strong carbonyl stretches around 1655 cm⁻¹ and 1709 cm⁻¹ (DEA Monograph).
Safety and Handling
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Hazards: As a potent synthetic cannabinoid, RH-34 is associated with severe and unpredictable health risks. Reported dangers include:
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Severe Toxicity: High risk of overdose leading to delirium, seizures, and acute kidney injury.
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Cardiovascular Effects: Tachycardia (rapid heart rate), extreme hypertension or hypotension, and chest pain.
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Psychiatric Effects: Can induce anxiety, paranoia, panic attacks, transient psychosis, hallucinations, and violent behavior.
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Dependence: Chronic use leads to dependence with a significant withdrawal syndrome.
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Handling: The availability of a DEA monograph implies that this substance is of regulatory concern and should be handled only by trained professionals in appropriate, controlled laboratory environments for forensic or research purposes.