Propranolol Hydrochloride CAS No. 3506-09-0

Product Description

Propranolol Hydrochloride is a non-selective β-adrenergic receptor blocker (β₁ and β₂ receptors) commonly used in the treatment of various cardiovascular and other medical conditions. It is a prescription medication available in different dosage forms, including tablets, sustained-release tablets, and injectable solutions. Its chemical name is 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride, with a molecular formula of C₁₆H₂₁NO₂·HCl and a molecular weight of 295.81 g/mol. Propranolol Hydrochloride is a white or off-white crystalline powder, odorless, slightly bitter, and easily soluble in water.

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Product Use & Characteristics

• Mechanism of Action: Propranolol works by blocking β₁ receptors in the heart, reducing heart rate, myocardial contractility, and cardiac output, thereby lowering myocardial oxygen consumption. It also blocks β₂ receptors, though the clinical impact on bronchoconstriction and vasoconstriction is minimal. Additionally, it inhibits renin release, reduces the activity of the renin-angiotensin-aldosterone system (RAAS), and has a membrane stabilizing effect at high doses.
• Clinical Applications: Propranolol Hydrochloride is widely used in cardiovascular diseases such as hypertension, angina pectoris, arrhythmia, myocardial infarction, and heart failure. It is also indicated for hyperthyroidism, pheochromocytoma, migraine prevention, anxiety disorders, and portal hypertension. Dosage varies depending on the condition being treated, with oral administration being the most common route.
• Adverse Reactions: Common side effects include bradycardia, hypotension, fatigue, dizziness, gastrointestinal disturbances, Raynaud phenomenon, and sleep disorders. Severe adverse reactions may include acute heart failure (especially upon sudden discontinuation) and rare severe allergic reactions.
• Contraindications: Propranolol Hydrochloride is contraindicated in patients with bronchial asthma or chronic obstructive pulmonary disease (COPD), severe bradycardia, second or third-degree atrioventricular block, cardiogenic shock, severe heart failure, and those allergic to beta-blockers.
• Precautions: Long-term use requires gradual dose reduction to avoid rebound hypertension or worsening of symptoms. Special populations such as diabetic patients, pregnant and lactating women, and those with hepatic dysfunction need careful monitoring and dose adjustment. Drug interactions with calcium channel blockers, insulin, oral hypoglycemics, and monoamine oxidase inhibitors should be carefully managed.
• Overdose Management: Symptoms of overdose include severe bradycardia, hypotension, heart failure, bronchospasm, and coma. Treatment involves gastric lavage, intravenous atropine, vasopressors, and possibly cardiac pacing or mechanical ventilation.
• Preparations and Specifications: Available as tablets (10 mg, 40 mg), sustained-release tablets (80 mg, 160 mg), and injection (1 mg/mL).

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Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.