2-(Ethylamino)-1-phenyl-1-pentanone
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Product Description
2-(Ethylamino)-1-phenyl-1-pentanone, also known as N-ethylpentedrone (NEP), is a β-keto-amine which is structurally related to cathinones, a class of substituted phenethylamines. It is classified as a Schedule I controlled substance due to its high potential for abuse and significant health risks. It is monitored in forensic chemistry due to its potential misuse.
Synthesis Methods
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Synthetic Cathinone Derivatives: Typically synthesized through chemical reactions involving the addition of functional groups to a basic ketone or amine structure. Specific methods would depend on the desired final structure and properties.
Uses and Applications
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Pharmacology: Potential stimulant or psychoactive effects, though specific testing and regulatory approval are required.
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Organic Synthesis: Can serve as an intermediate in synthesizing more complex molecules.
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Forensic Chemistry: Monitored due to potential misuse.
Molecular Formula and Composition
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Molecular Formula: C₁₃H₁₉NO
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Atomic Composition:
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Carbon (C): 13 atoms
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Hydrogen (H): 19 atoms
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Nitrogen (N): 1 atom
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Oxygen (O): 1 atom
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Molecular Weight: 205.292 g/mol
Structural Analysis
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Pentanone Backbone: Five-carbon ketone chain with the carbonyl group (C=O) at carbon 1.
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Phenyl Group: Attached to the carbonyl carbon (carbon 1).
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Ethylamino Group: Attached to the second carbon of the pentanone chain.
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Structural Formula: C₆H₅-C(O)-CH(NH-CH₂-CH₃)-CH₂-CH₂-CH₃
Functional Groups
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Ketone: Carbonyl group (C=O) at position 1.
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Amine: Ethylamino group (-NH-CH₂-CH₃) as a secondary amine.
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Aromatic Ring: Phenyl group (C₆H₅).
Physical and Chemical Properties
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Physical State: Likely a liquid or low-melting solid at room temperature.
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Solubility:
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Polar Solvents: Moderate solubility in polar solvents like water or ethanol.
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Non-polar Solvents: Soluble in organic solvents like hexane or dichloromethane.
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Boiling/Melting Point: Likely higher than simple ketones, possibly in the range of 200–300°C.
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Reactivity:
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Ketone Group: Reactive toward nucleophiles.
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Amine Group: Can act as a base or nucleophile, forming salts with acids.
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Phenyl Group: Relatively unreactive but can participate in electrophilic aromatic substitution.
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Degree of Unsaturation
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Degree of Unsaturation (DU): 5
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4 from the phenyl ring (1 for the ring, 3 for the double bonds in benzene).
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1 from the carbonyl group (C=O).
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Hydrogen Bonding
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Amine (-NH): Can act as a hydrogen bond donor and acceptor.
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Ketone Oxygen: Can act as a hydrogen bond acceptor.
Legality and Hazards
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Legal Status: Classified as a Schedule I controlled substance in many countries, including the United States, the United Kingdom, and China.
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Primary Hazards and Side Effects:
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Severe agitation and paranoia.
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Prolonged duration of effects (8-12 hours or more).
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Cardiovascular toxicity (tachycardia, hypertension, chest pain).
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Hyperthermia.
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Psychosis (hallucinations, delusions).
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Serotonin syndrome.
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Crucial Warning: Frequently implicated in overdoses, hospitalizations, and fatalities. Often found as an adulterant in tablets sold as "ecstasy" or "Molly," leading to unexpected and severe reactions.