Retatrutide
Founded in 2017, Sigma Chemical Co., Ltd. supplies over 100 countries with high-quality chemicals. We are dedicated to safety, innovation, and global cooperation.
Product Description
Retatrutide is a novel triple agonist targeting glucagon receptors, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) receptors, currently under investigation for its potential use in treating type 2 diabetes and obesity. In clinical trials, retatrutide has demonstrated significant efficacy in reducing body weight and improving glycemic control. For instance, in the phase 2 substudy published in The Lancet Diabetes & Endocrinology, retatrutide showed substantial reductions in total body fat mass compared to placebo and dulaglutide, with participants experiencing up to 26.1% reduction in total fat mass at the 8 mg dose. The study also highlighted that retatrutide maintained a favorable ratio of fat mass loss to lean mass loss, which is crucial for overall metabolic health. Additionally, retatrutide's innovative mechanism of action, which synergistically enhances insulin secretion and improves glucose homeostasis, positions it as a promising therapeutic option. Ongoing phase 3 clinical trials, such as NCT06354660, aim to further validate its efficacy and safety in larger populations, potentially revolutionizing the management of type 2 diabetes and obesity.
Synthesis Methods
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Laboratory Synthesis: Retatrutide is synthesized through complex chemical processes involving multiple steps, including peptide synthesis and purification. Specific details of the synthesis process are proprietary and not publicly disclosed.
Uses
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Medical Applications:
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Type 2 Diabetes Management: Retatrutide is under investigation for its potential use in managing type 2 diabetes by improving glycemic control and reducing body weight.
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Obesity Treatment: It is being studied for its efficacy in reducing body weight and improving metabolic markers in individuals with obesity.
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Cardiometabolic Health: Retatrutide has shown potential in improving cardiometabolic health by reducing blood pressure and improving lipid profiles.
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Research and Development:
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Pharmaceutical Research: Used in preclinical and clinical studies to explore its therapeutic potential.
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Academic Research: Studied in academic settings to understand its mechanism of action and potential applications.
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Properties and Characteristics
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Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
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Molecular Weight: 4731 g/mol
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CAS Number: 2381089-83-2
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Form: Powder
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Storage Conditions: Store at <-15°C, keep container tightly closed when not in use
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Physical State: Solid
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Color: Not specified
Safety and Handling
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First Aid Measures:
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Eye Contact: Immediately flush eyes with plenty of flowing water for 10-15 minutes, holding eyelids apart. Consult an ophthalmologist.
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Skin Contact: Wash immediately with plenty of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Wash contaminated clothes before reuse. Call a physician.
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Ingestion: Wash out mouth with water if the person is conscious. Call a physician.
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Inhalation: Remove the casualty to fresh air and keep warm and at rest. If breathing is irregular or stopped, administer artificial respiration. Call a physician.
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Handling Precautions:
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Avoid contact with skin, eyes, and clothing.
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Avoid ingestion and inhalation.
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Avoid prolonged or repeated exposure.
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Wash thoroughly after handling.
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Storage Conditions:
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Store at <-15°C.
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Keep container tightly closed when not in use.
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Warm to room temperature before use.
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Keep away from incompatible substances.
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Regulatory and Compliance
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Regulatory Status:
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REACH Registration: Not applicable as the substance or its uses are exempted from registration or the annual tonnage does not require registration.
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Hazard Classification: Not classified for physical, health, or environmental hazards.
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Label Elements:
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Precautionary Statements: P261 (Avoid breathing dust/fume/gas/mist/vapours/spray), P262 (Do not get in eyes, on skin, or on clothing).
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Environmental and Disposal
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Environmental Precautions:
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Do not allow to enter soil/subsoil, surface water, or drains.
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Ensure all waste water is collected and treated via a waste water treatment plant.
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Disposal:
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Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and exhaust air.
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Dispose of waste according to local laws and regulations.
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