RTI-113 hydrochloride CAS No. 141807-57-0

Pharmacology:

• Dopamine Reuptake Inhibitor (DRI): RTI-113 specifically blocks the reuptake of dopamine in the brain, increasing dopamine levels.

• Selectivity: Highly selective for the dopamine transporter (DAT) with minimal effects on other neurotransmitters like serotonin (SERT) or norepinephrine (NET).

• Cocaine Analog: Structurally related to cocaine but with modified chemical properties.

• Potency and Duration: More potent and longer-acting than cocaine, with IC50 values around 1.98 nM for DAT binding.

• Behavioral Effects: Maintains similar behavioral effects to cocaine but with higher potency and slower onset in some analogs.

Uses

Scientific Research:

• Addiction Studies: Used in animal models to understand the neurobiology of the brain's reward system and the mechanisms of addiction.

• DAT Occupancy: Studied via PET imaging, showing high DAT occupancy (94-99%) at effective doses compared to 65-76% for cocaine.

• Therapeutic Potential: Investigated as a potential treatment for cocaine addiction due to its high potency, high efficacy, and longer duration of action.

Research Tool:

• Pharmacological Research: Primarily used as a tool in pharmacological research to study the effects of dopamine reuptake inhibition.

Chemical Structure:

• Systematic Name: Phenyl (1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride

• Molecular Formula: C₂₁H₂₃Cl₂NO₂

• Molecular Weight: 392.32 g/mol

• CAS Number: 141807-57-0

• SMILES: CN1C2CCC1C@HC(=O)OC4=CC=CC=C4.Cl

• InChI: InChI=1S/C21H22ClNO2.ClH/c1-23-16-11-12-19(23)20(21(24)25-17-5-3-2-4-6-17)18(13-16)14-7-9-15(22)10-8-14;/h2-10,16,18-20H,11-13H2,1H3;1H/t16-,18+,19+,20-;/m0./s1

Physical Properties:

• Appearance: Typically a solid powder, often white or off-white.

• Solubility: Highly soluble in water and polar solvents like methanol or ethanol.

• Stability: Stable at room temperature when stored properly (away from light and moisture).

Safety and Handling

Hazards:

• Acute Toxicity: Harmful if swallowed (H302).

• Skin Irritation: Causes skin irritation (H315).

• Eye Irritation: Causes serious eye irritation (H319).

• Respiratory Irritation: May cause respiratory irritation (H335).

Precautions:

• Protective Measures: Wear protective gloves, protective clothing, eye protection, and face protection.

• First Aid: Rinse with water for skin and eye contact, move to fresh air for inhalation, and consult a physician.

Regulatory and Legal Status

Controlled Substance:

• Schedule II: Classified as a Schedule II controlled substance in the United States under the Controlled Substances Act due to its structural and pharmacological similarity to cocaine.

• International Control: Similarly controlled in many other countries.

Disposal and Transport

Disposal:

• Licensed Disposal: Offer surplus and non-recyclable solutions to a licensed disposal company.

• Contaminated Packaging: Dispose of as unused.

Transport:

• Not Dangerous Goods: Not classified as dangerous goods for transport purposes.

Product Documents

• Safety Data Sheet (SDS)
• Certificate of Analysis
• Product Brochure
• Technical Data Sheet