Copper chlorophyllin CAS No. 65963-40-8

Product Description

Copper chlorophyllin is a semi-synthetic derivative of chlorophyll, the green pigment found in plants, where the central magnesium atom is replaced by copper. It is a water-soluble compound, offering greater hydrophilicity, tinctorial power, and stability under heat, light, and acidic conditions compared to natural chlorophyll. This makes it highly versatile for various applications. It is primarily used as a food colorant (E141 or Natural Green 3) in products like candies, gums, ice creams, and beverages. Additionally, it is used in dietary supplements for potential health benefits such as detoxification, wound healing, and antioxidant properties, though scientific evidence for these benefits is limited. Copper chlorophyllin is also found in medical and cosmetic products for its wound-healing and odor-control properties. It is generally recognized as safe (GRAS) in small amounts, but high doses may cause mild gastrointestinal upset or green discoloration of urine and feces. It is not recommended for pregnant or nursing women without medical advice.

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Product Use & Characteristics

Properties of Copper Chlorophyllin

• Molecular Formula: C₃₄H₃₄CuN₄O₆

• Molecular Weight: 658.2 g/mol

• IUPAC Name: Copper;[(17S,18S)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-18,24-dihydro-17H-porphyrin-2-ylidene]methanediolate

• Appearance: Dark green to blue-green powder

• Solubility: Water-soluble (unlike natural chlorophyll, which is fat-soluble)

• Stability: More stable than natural chlorophyll under heat and light conditions

• Central Atom: Copper (Cu) replaces the magnesium (Mg) found in natural chlorophyll

Uses of Copper Chlorophyllin

Food Coloring

• E141 (Natural Green 3): Used as a natural green colorant in various food products such as:

  • Candies

  • Gums

  • Ice creams

  • Beverages

  • Canned vegetables

  • Sauces

Dietary Supplements

• Marketed for potential health benefits, including:

  • Detoxification

  • Wound healing

  • Antioxidant properties

  • Internal deodorization (reducing body odor)

Medical and Cosmetic Applications

• Topical Use: In creams and ointments for wound healing and odor control

• Investigated Effects: Preliminary research explores potential anti-cancer and anti-inflammatory effects

Deodorant Agent

• Added to:

  • Soaps

  • Mouthwashes

  • Deodorants

  • For its odor-neutralizing properties

Safety and Side Effects

• GRAS Status: Generally recognized as safe (GRAS) in small amounts

• Potential Side Effects:

  • Green discoloration of urine or feces

  • Mild digestive upset (e.g., diarrhea, abdominal cramps)

  • Photosensitivity (increased skin sensitivity to sunlight)

• Cautions:

  • Not recommended for pregnant or nursing women without medical advice

  • Use with caution in children due to limited safety data

  • Long-term use (beyond 3 months) in medicinal doses is not well-established

Comparison with Natural Chlorophyll

Feature	Copper Chlorophyllin	Natural Chlorophyll
Solubility	Water-soluble	Fat-soluble
Central Atom	Copper (Cu)	Magnesium (Mg)
Stability	More stable	Degrades easily
Applications	Supplements, food dye	Limited (oil-based)

Potential Benefits (Research Ongoing)

• Antioxidant Properties: Minimizes lipid peroxidation

• Antimutagenic Properties: Neutralizes mutagenic compounds

• Anti-inflammatory Effects: Suggested by some studies

• Skin Health: Improves photoaged skin, reduces acne, decreases pore size

• Odor Control: Traditionally used for various body odors

• Blood-building (Indirectly): Chlorophyll-rich foods may aid in conditions like anemia

Important Considerations

• Pregnancy and Breast-feeding: Insufficient safety data; best to avoid use

• Children: Use with caution due to copper content and limited safety data

• Long-term Use: Safety beyond 3 months in medicinal doses is not well-established

• Consultation: Always consult a healthcare provider before starting any new supplement, especially if you have existing health conditions or are taking other medications

Why us!

Sigma Chemical Group is a major chemical enterprise headquartered in Hangzhou, Zhejiang Province, with a diversified portfolio of subsidiaries including Qingdao Sigma Chemical Co., Ltd., Henan Sigma Biotechnology Co., Ltd., Nanchang Sigma Chemical Co., Ltd., and Jinan Sigma Chemical Co., Ltd. Established on January 16, 2017, Qingdao Sigma Chemical Co., Ltd. operates as a micro-sized chemical product wholesaler with a registered capital of RMB 100,000. Led by legal representative Yang Yuwen and based at 2-1-2301, Jiahe Xinxing, No. 130 Shandong Road, Shibei District, Qingdao, the company’s operations span chemicals, machinery equipment, and import-export services. Henan Sigma Biotechnology Co., Ltd., located in Dongmafang, Muye District, Xinxiang City, Henan Province, specializes in the sales of pesticides, pharmaceuticals, veterinary drugs, and mixed feed additive series, including products like adenine, florfenicol injection, carbasalate calcium soluble powder, and cefotaxime sodium chloride injection. Guided by a win-win and innovative business philosophy, the company employs a modern management approach and customer-centric service, upholding integrity, diligence, and a commitment to quality, thereby earning customer trust through diverse product offerings and competitive pricing. Nanchang Sigma Chemical Co., Ltd., situated in Nanchang, Jiangxi Province, is dedicated to producing high-purity plant extracts, emphasizing eco-friendly, non-toxic chemical raw materials that generate no environmental pollutants. Jinan Sigma Chemical Co., Ltd., located in Jinan, the capital of Shandong Province known as the "City of Springs," focuses on manufacturing active pharmaceutical ingredients (APIs) and pharmaceutical intermediates. The company maintains long-term industry-academia-research collaborations with Shandong University and Qilu University of Technology, continuously enhancing R&D investments to drive innovation and growth.