Ibutamoren CAS No. 159634-47-6

Product Description

Ibutamoren is an investigational drug and a growth hormone secretagogue that mimics the action of ghrelin by binding to and activating the ghrelin receptor (GHS-R) in the brain. This activation stimulates the pituitary gland to release growth hormone (GH) and insulin-like growth factor 1 (IGF-1), potentially leading to increased muscle mass, improved bone density, enhanced recovery, and better sleep quality. However, it is important to note that Ibutamoren is not approved for human consumption by the FDA or EMA and is banned by WADA for athletic use. Potential side effects include increased appetite, weight gain, fluid retention, insulin resistance, joint pain, and other adverse reactions. As an investigational drug, its use is restricted, and further research is needed to fully understand its benefits and risks.

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Product Use & Characteristics

Properties and Characteristics

• Molecular Formula: C27H36N4O5S

• Molecular Weight: 528.7 g/mol

• IUPAC Name: 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide

• Chemical Structure: Ibutamoren is a small molecule, non-peptide growth hormone secretagogue (GHS) with high oral bioavailability and a long biological half-life, suitable for once-daily administration.

Mechanism of Action

• Ibutamoren functions by mimicking the action of ghrelin, a natural hormone that stimulates the release of growth hormone (GH) from the pituitary gland.

• It binds to and activates the growth hormone secretagogue receptor (GHSR), leading to increased secretion of GH and insulin-like growth factor 1 (IGF-1).

• The activation of GHSR by ibutamoren results in a pulsatile release of GH, which is regulated by insulin-like growth factor feedback mechanisms to prevent overstimulation.

Uses and Applications

• Medical Research: Ibutamoren is an investigational drug studied for its potential to restore GH secretion in older adults to levels observed in younger individuals, improving muscle mass, bone density, and overall physical function.

• Clinical Trials: It has been evaluated in clinical trials for conditions such as growth hormone deficiency, sarcopenia, frailty, osteoporosis, and nonalcoholic fatty liver disease.

• Performance Enhancement: Due to its potential to increase muscle mass and strength, ibutamoren has been studied for its effects on physical performance and recovery, although its use for performance enhancement is banned by the World Anti-Doping Agency (WADA).

Metabolism and Detection

• Human Metabolism: Studies have shown that ibutamoren and its metabolites can be detected in human urine samples for up to 4 days after a single oral administration, with hydroxylated metabolites being a promising target for detection.

• Equine Metabolism: In thoroughbred horses, 22 metabolites of ibutamoren were identified, with major metabolites detectable up to 96 hours after a single dose. The study also detected hydroxylated metabolites, dissociated side chains, and glucuronic acid conjugates.

• Detection Methods: Liquid chromatography/high-resolution mass spectrometry (LC-HRMS) is commonly used to detect and characterize ibutamoren and its metabolites in biological samples.

Legal and Regulatory Status

• FDA and EMA: Ibutamoren is not approved for therapeutic use by the FDA or EMA.

• WADA: It is banned for use in competitive sports due to its potential for performance enhancement.

Potential Benefits and Risks

• Benefits: Increased muscle mass and strength, improved bone density, enhanced recovery, better sleep quality, and potential anti-aging effects.

• Risks: Increased appetite and weight gain, fluid retention, insulin resistance, joint pain, and potential for cancer growth due to elevated IGF-1 levels.

Why us!

Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.