Cyclazodone CAS No. 14461-91-7

Product Description

Warning: This product is for research use only and is not for clinical use.

Cyclazodone is a central nervous system stimulant first synthesized by the American Cyanamid Company in the 1960s. It is a homologue of pemoline and tozalinone, characterized by a 2-(phenylmethyl)-4,5-dihydro-1H-imidazol-4-one core (molecular weight 216.24 g/mol) connected by an imidazoline ring and benzyl substituents. Preclinical data suggest that it has a wider therapeutic index and safety margin than pemoline. Mechanistic studies suggest that it acts primarily as a dopamine-norepinephrine reuptake inhibitor, with attention-enhancing, wakefulness-promoting, and putative nootropic effects comparable to methylphenidate. Despite these favorable properties, cyclopidogrel has never received regulatory approval for human use and is currently classified only as an investigational chemical. Reported adverse effects are similar to those of other stimulants—insomnia, anxiety, tachycardia, and potential for dependence—while its chronic toxicity and overall risk profile are largely unknown due to the lack of long-term controlled studies.

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Product Use & Characteristics

• Chemical Identity

  • Molecular Formula: C₁₂H₁₂N₂O₂

  • Molecular Weight: 216.24 g mol⁻¹

  • IUPAC Name: 2-cyclopropylimino-5-phenyl-1,3-oxazolidin-4-one

  • Other Names: Ciclazodona, Cyclopropylpemoline, Cyclazodonum

• Origin & Synthesis

  • Developer: American Cyanamid Company (1960s)

  • Patent: US 3,321,470 A (1967)

  • Structural Class: 4-oxazolidinone imine; aminorex analogue and congener of thozalinone and pemoline

• Pharmacology & Effects

  • Mechanism: Putative dopamine–norepinephrine reuptake inhibitor (DNRI) with mild psychostimulant activity

  • Observed Actions in Animals:

    • Strong, long-lasting increase in spontaneous locomotor activity (mice, 10 mg kg⁻¹ i.p.)

    • ~5× more potent than thozalinone

    • Minimal cardiovascular or sympathomimetic side-effects relative to amphetamines

    • Reported absence of psychological dependence in early studies

  • Human Anecdotes (Reddit 2021–2022): Mild euphoria, clearer focus, “gentler Adderall”

• Uses / Intended Applications

  • Historical indications: psychotonic agent for depressive states, anti-fatigue, anorexigenic (weight-loss) aid

  • Contemporary: unapproved research chemical / nootropic; declared a prohibited substance by the World Anti-Doping Agency (WADA)

• Safety & Adverse Effects

  • Acute Overdose (animal data): Irregular/involuntary muscle contractions, convulsions

  • Reported Human Side-effects: Insomnia, anxiety, tachycardia, potential dependence

  • Long-term Toxicity: No controlled human data; chronic visual disturbances (mydriasis, ophthalmoplegia, proptosis) reported in stimulant abuse literature

  • Regulatory Status: Not approved for medical use in any major jurisdiction; listed as a banned stimulant in sport

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