Atomoxetine CAS No. 83015-26-3

Product Description

Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI) originally named Strattera® for the treatment of attention deficit hyperactivity disorder (ADHD). Structurally, it is a secondary amino compound with cresyl aromatic ether features, which allows it to selectively block the norepinephrine transporter (NET) without significantly inhibiting the dopamine transporter (DAT) in subcortical areas—a key advantage over stimulants as it minimizes abuse potential while enhancing norepinephrine and dopamine levels in the prefrontal cortex (PFC), thereby improving executive function, attention, and impulse control. Beyond ADHD, emerging evidence from recent clinical studies such as hemodialysis-associated hypotension and cocaine use disorder highlights the versatility of atomoxetine, demonstrating its effectiveness in stabilizing blood pressure through sympathomimetic mechanisms and reducing decision impulsivity through modulation of norepinephrine signaling, making it a promising off-label treatment for autonomic dysfunction and addiction-related cognitive deficits.

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Product Use & Characteristics

Chemical Identity & Structure

• IUPAC Name: (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine

• Molecular Formula: C₁₇H₂₁NO

• Molecular Weight: 255.35 g/mol

• Structure:

  • Secondary amine with methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents.

  • Aromatic ether functional group.

  • Toluene derivative (methyl-substituted benzene ring).

Pharmacological Classification

• Primary Mechanism:

  • Selective Norepinephrine Reuptake Inhibitor (NRI) → Enhances extracellular norepinephrine (NE) and dopamine (DA) in the prefrontal cortex (PFC).

• Secondary Targets:

  • Serotonin Transporter (SERT) antagonist (PET studies in rhesus monkeys).

  • NMDA receptor blockade (glutamatergic system modulation).

Approved & Investigational Uses

Indication	Status	Key Notes
ADHD (Attention-Deficit/Hyperactivity Disorder)	FDA-approved (6–18 years; marketed as Strattera®).	Non-stimulant alternative to methylphenidate/amphetamines.
Autism Spectrum Disorder (ASD) with ADHD	Off-label (3–6 years)	Retrospective studies show efficacy & tolerability.
Cocaine Use Disorder (CUD)	Experimental	Reduces decisional impulsivity & attentional deficits.
Orthostatic Hypotension	Case report	25 mg/day stabilized BP in hemodialysis patients.

Pharmacokinetics & Metabolism

• Metabolism:

  • CYP2D6 substrate (genetic polymorphism affects efficacy/side effects).

• Half-life: ~5 hours (poor metabolizers: 24 hours).

• Peak Plasma: 1–2 hours post-dose.

Adverse Effects & Monitoring

• Common (ADHD trials):

  • GI upset (nausea, appetite loss), aggression, hyperactivity.

• Rare but Serious:

  • Suicidal ideation (black-box warning for children/adolescents).

  • QTc prolongation (ECG monitoring required).

Formulation & Delivery

• Commercial: Capsules (10–100 mg).

• 3D Printing:

  • Selective Laser Sintering (SLS) enables personalized tablets with tunable release profiles.

  • Excipients: HPMC (matrix), mannitol, Candurin® Gold Sheen (laser absorber).

Regulatory & Research Highlights

• FDA Approval: 2002 (ADHD).

• Clinical Trials:

  • CUD: 40 mg single dose improves Flanker task accuracy & PFC-amygdala connectivity.

  • ASD: 1.2–1.8 mg/kg/day effective in 82.7% of children.

Why us!

Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.