Etidronate disodium CAS No. 7414-83-7

Product Description

Etidronate disodium is a first-generation bisphosphonate that slows down excessive bone turnover by binding to hydroxyapatite crystals and inhibiting osteoclast activity, thereby reducing bone resorption. The drug is primarily used to treat Paget's disease of bone, heterotopic ossification (e.g. after hip surgery or spinal cord injury), and hypercalcemia caused by malignant tumors; it can also be used to treat postmenopausal or male osteoporosis when newer drugs are not applicable. The usual oral dose is 20 mg per day, taken with a glass of water on an empty stomach, and then taken upright for at least 30 minutes; the dose will be adjusted according to other indications. Common adverse reactions include gastrointestinal discomfort (nausea, diarrhea), headache, and musculoskeletal pain. Rare but serious risks of long-term treatment include osteonecrosis of the jaw and atypical femoral fractures. Calcium, iron, and antacids must be taken separately to avoid interference with absorption, and patients with renal insufficiency or esophageal disease should take it with caution. Note: We supply etidronate disodium raw materials, not finished drugs.

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Product Use & Characteristics

1. Identity & Chemistry

   IUPAC Name: disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

   Molecular Formula: C₂H₆Na₂O₇P₂

   Molecular Weight: 249.99 g·mol⁻¹

   Synonyms: Etidronate disodium, Disodium etidronate, Sodium etidronate, Disodium ethydronate

   Description: White crystalline powder; complies with CP/USP/EP/BP standards

2. Properties & Characteristics

   Class: First-generation, non-nitrogen bisphosphonate (pyrophosphate analogue)

   Solubility: Highly water-soluble; strong chelator of divalent cations (Ca²⁺, Cu²⁺)

   Stability: Non-volatile, resistant to enzymatic hydrolysis; no UV chromophore

   Packaging: 25 kg fibre-drum, cool & dry storage

3. Mechanism of Action

   Binds to hydroxyapatite crystals in bone matrix, inhibiting osteoclast-mediated resorption

   Reduces extra-skeletal calcification by blocking crystal formation/dissolution

   Induces osteoclast apoptosis via ATP-mimetic inhibition

4. Therapeutic Uses

   Paget’s disease of bone

   Post-menopausal & male osteoporosis (cyclical regimens)

   Heterotopic ossification (after hip surgery, spinal cord injury)

   Hypercalcaemia of malignancy

   Bone metastases & multiple-myeloma bone disease

   Calcific uraemic arteriolopathy (calciphylaxis) – case-report success

   Generalised arterial calcification of infancy (GACI) – off-label paediatric use

5. Dosage & Administration

   Standard oral: 200–400 mg daily on empty stomach, or 200 mg day⁻¹ × 14 days every 12 weeks (cyclical)

   Paediatric GACI: ≈ 18 mg kg⁻¹ day⁻¹ until arterial calcification regresses

   Intravenous infusion for severe hypercalcaemia

6. Adverse Effects & Precautions

   Common: GI upset (nausea, diarrhoea), headache, bone pain
   Rare/Serious: osteonecrosis of jaw, atypical subtrochanteric fractures, hypophosphataemic rickets with long-term high-dose use
   Administration: Remain upright ≥30 min; separate from calcium/iron; monitor renal function

7. Analytical & Detection Methods

   HPLC-CAD (mixed-mode column): 8-min stability-indicating assay for release & stability testing

   Fluorescent “turn-off–on” sensor: N,S-doped carbon dots (microwave 60 s) detect Cu²⁺ or etidronate (linear range 30–210 µM)

8. Industrial Synthesis

   Reaction of phosphorus trichloride with acetic acid → etidronic acid → controlled neutralisation with NaOH → Etidronate disodium (pharmacopoeia-grade).

Why us!

Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.