Sodium Bicarbonate CAS No. 144-55-8

Product Description

Sodium bicarbonate—better known as baking soda—is a white, odorless crystalline powder that is mildly alkaline (pH ≈ 8.3) and readily dissolves in water. Its signature talent is in the kitchen, where it reacts with acidic ingredients like buttermilk or lemon juice to release carbon-dioxide bubbles that make cakes and breads rise. Beyond baking, the same gentle reactivity makes it a versatile workhorse: it neutralizes stomach acid for quick heartburn relief, scrubs and deodorizes household surfaces, and appears in toothpastes and mouthwashes to whiten teeth and freshen breath. Hospitals use intravenous sodium bicarbonate to correct metabolic acidosis, while fire extinguishers rely on it to smother Class B and C fires. Although generally safe in small amounts, excessive ingestion can upset the body’s electrolyte balance or cause alkalosis, so prolonged antacid use should be medically supervised.

Product Use & Characteristics

Properties & Characteristics

• Chemical formula: NaHCO₃

• Molar mass: 84.01 g/mol

• White crystalline powder or nanoparticles; odorless

• Solubility: 9.6 g/100 mL (25 °C)

• pH (1 % solution): ~8.3 (mildly alkaline)

• Decomposes >50 °C → Na₂CO₃ + CO₂ + H₂O

• GRAS, non-toxic, biodegradable

Synthesis / Production

• Solvay Process: CO₂ + NH₃ + NaCl + H₂O → NaHCO₃

• Microemulsion: Oil/water/surfactant → NaHCO₃ nanoparticles

• Electro-spray drying: Inhalable powders

Uses / Applications

• Sports ergogenic aid: Enhances Wingate, Yo-Yo, rowing, 45 s–8 min endurance

• CKD therapy: Corrects metabolic acidosis (serum HCO₃⁻ <22 mmol/L)

• Water treatment: Mn(II)/PAA activator, degrades pharmaceuticals via Mn(V)

• Cancer immunotherapy: NaHCO₃ nanoparticles neutralize tumor acidity, induce pyroptosis

• Food: Leavening agent, pH regulator

• Pharmacy: Antacid, effervescent tablets, dialysate buffer

Mechanisms

• Exercise: Buffers muscle acidosis, delays fatigue

• CKD: Replenishes bicarbonate, reduces ammoniagenesis

• Contaminant oxidation: Generates Mn(V)-HCO₃⁻ reactive species

• Cancer: Acid neutralization → pyroptosis → immune activation

Dosage & Administration

• Exercise (acute): 0.2–0.3 g kg⁻¹ 90–180 min pre-exercise

• Exercise (multi-day): 4 × 125 mg kg⁻¹ day⁻¹ for 5–7 days

• CKD: 0.3–0.8 mEq kg⁻¹ day⁻¹ (1.2–3 g/70 kg) titrated to serum HCO₃⁻ ≥22 mmol/L

• Nanoparticles: Intravenous/intratumoral (pre-clinical models)

Adverse Effects & Contra-indications

• GI upset (nausea, bloating)

• Sodium-load concerns (no BP rise seen in CKD meta-analysis)

• Risk of metabolic alkalosis if overdosed

• Nanoparticles: potential hypernatremia

Evidence Grade

• Exercise: Moderate-quality meta-analyses

• CKD BP safety: Moderate-certainty RCT meta-analysis (14 RCT, 2110 participants)

• Water treatment: Bench-scale proof-of-concept

• Cancer therapy: Pre-clinical murine data

Formulation Variants

• Bulk powder/tablets

• Enteric-coated capsules

• Nanoparticles (~50–200 nm)

• Effervescent granules

Research Gaps

• Female-specific dosing (under-representation)

• Long-term nanoparticle safety

• Acute vs multi-day vs chronic protocols

• Combination therapies (e.g., NaHCO₃ + β-alanine, immune checkpoint inhibitors)

Why us!

Qingdao Sigma Chemical Co., Ltd., established in January 2017 and headquartered in Qingdao, China, is a reliable chemical supplier. Specializing in pharmaceuticals, biochemical intermediates, and research chemicals, the company offers a diverse product portfolio, including peptides (e.g., Tirzepatide, Semaglutide), nootropics, veterinary products, and APIs, often marketed with ≥99% purity and COA certification. We provides R&D, custom synthesis, and contract manufacturing services at various scales, while claiming a global export presence across 100+ countries. With international warehouses in the USA, Europe, Australia, and Canada, Qingdao Sigma Chemical also facilitates drop-shipping and reshipments, positioning itself as a key supplier for laboratory and research applications.